You can do Indi Fury, Geo Frail and entrust Indi Malaise or Indi Acumen, Geo Malaise, entrust Indi Frailty or any combo really, damage cap is 99,999 anyway and you'll hit that regularly with Niq ring and the DA from Nyame pieces. Doji is always best.
It's kinda true, but there is still optimal approach.
If you have Dia iii, ja enhanced GEO frailty with Idris on top of that will lower def enough, that you won't even need fury. Now most mobs has 100-112 mdb and 50mdb is the lower limit, so Ja enhanced GEO malaise will often be too much. Indi frailty is also probably the worst approach. Stacking def down is way better than stacking attack%.