Got 5/5 malignance today! For my pieces it went something like this:
Started on VE spam on THF with TH8+:
Got daybreak, malig sword/pole, earring and malignance pants within the first 50 or so runs
From there I went over 120+ VE runs without seeing a single drop until finally malignance gloves dropped. I was almost about to take a break at this point but decided to keep pushing forward due to the drop. However, I was very hesitant to continue spamming VE because at that rate it might've taken 300+ more runs before I got all 5 pieces. I decided to give MNK/THF a try, with only TH2 from sub, on E. It took some getting used to but with monk's natural subtle blow and higher damage, I was able to consistently kill her within 3 minutes (ken+1 set and karambit).
This is where I started to really see drops. I ended up getting malignance hat about 15-20 E runs in and then the tabard dropped maybe 10 runs after that. Then after another 20 runs, the last piece dropped for me.
I am sure I got very lucky with this final set of drops, but I truly think the jump to E from VE was worth it, even though I had to give up a lot of TH (from TH8-9 to TH2), but it seems for sure E has a higher drop rate than VE.
Here's a summary:
First 50~ VE runs (THF /w TH8+) - polearm/sword/earring/club + 1 piece of malig armor
Next 150~ VE runs (THF /w TH8+) - 2nd piece of malig armor
Final 50 E runs (MNK/THF /w TH2) - last 3(!) pieces of malig armor
Trusts: AAEV, Ajido-Morujido (necessity for E), Joachim, Koru-Moru, Yoran-Oran